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Sankara Nethralaya
Sankara Nethralaya
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Back to Biochemistry
Department of Biochemistry and Cell Biology
Projects
On Going Projects
S.No Title of the projects & PI Funding Agency & No. Duration
01

Characterization of a novel 88 kDa protein found in patients with Eales’ disease, Uveitis, tuberculosis, leprosy and rheumatoid arthritis
(PI: Dr. K.N. Sulochana)

ICMR
53/9/2001
2 years
2011-14
02

Adiponectin as a “therapeutic target” for ocular angiogenesis
(PI: Dr. K.N. Sulochana)

ICMR
5/4/6/6/09-NCD II
3 years
2010-13
03

Development of siRNA by targeting copper regulators to control angiogenesis (PI: Dr. K.N. Sulochana)

DBT
PR/2885/AGR/36/620/09
3 yrs
2010-13
04

Development of a simple fluorescent assay for serum LOX activity (PI: Dr. K.N. Sulochana)

ICMR
52/6/2009-BMS
2 yrs
2011-13
05 Design and development of small therapeutic peptide to target Angiogenesis by regulating LOX (PI: Dr. K.N. Sulochana) CSIR
27(0241)/10/EMR II
3 years
2011-14
06 Development of therapeutic peptides from small proteoglycan LRR family for the inhibition of tumor angiogenesis. (PI: Dr. K.N. Sulochana) DBT PR13198/Med/30/245/09 3 yrs
2011-13
07 Development of modulators of ODC for the therapeutic application in retinoblastoma (PI: Dr. K.N. Sulochana) CSIR 02/105)/12/EMR II 3 yrs
2012-15
08 Identification of interacting partners for PEDF in causing anti-angiogenesis (PI: Dr. K.N. Sulochana) DST SR/SO/JS/0099/2010 3 yrs
2012-15
09 Contact Lens wear induced changes in KC patients at the level of Redox status, inflammatory cytokines and collagen cross linking (PI: Dr. N. Angayarkanni) ICMR
5/4/6/16/Oph/11-NCD-II
3yrs
2012-15
10 Screening of the AMD patients for PON polymorphism and its functional correlation at the level of the PON activity, OxLDL and Hcy in the blood(PI: Dr. N. Angayarkanni) DBT: BT/PR13630/BRB/10/776/2010 3 yrs
2011-14
11 Effect of pesticide chlorpyrifos on the proteome of human retinal pigment epithelial cell line ARPE-19. Effect of cytoprotective agents on chlorpyriphos induced cytotoxicity. (PI: Dr. N. Angayarkanni) ICMR-5/8/4/18(ENV)/08/NCD-1 3 yrs
2010-13
12 Investigation into the role of Lipids, Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth factor in Diabetic Retinopathy (PI: Dr. N. Angayarkanni) DBT
PR11627/MED/30/157 2008
3 yrs
2010-13
13 Analysis of trace elements from donor eye balls with ARMD
(PI: Dr. K Coral)
CSIR
27(0264)/12/EMRII
3 years
2012-15
14 Investigating the therapeutic potential of LOX propeptide in angiogenesis and tumorogenesis (PI: Dr. K Coral) DST
SR/FT/LS-139/2010
3 years
2012-15
15 Regulation of SNARE exocytotic machinery under physiological and pathological conditions of diabetes (PI: Dr. J. Subbulakshmi) DST SR/FT/LS-145/2010 3 years
2012-15
16 Role of adiponectin on the integrity of Blood retinal
barrier during diabetic retinopathy using an in vitro 3D
cell culture model. (PI: Dr. J. Subbulakshmi)
DBT (RGYI) PR15023/GBD/27/282/10 3 years
2011-14
17 Understanding the effect of Adiponectin mediated signaling pathways on retinal degeneration using human retinal explant culture for designing efficient neuroprotective agent . (PI: Dr. J. Subbulakshmi) BT/PR055/MED/30/761/2012). 3 years
2012-15
 
Completed Projects (2011-12)
S.No Title of the projects Funding Agency & No. Duration
01

Tear Proteomics profile in Rheumatoid arthritis patients associated with and without Dry eye syndrome
(PI: Dr. N. Angayarkanni)

DBT
PR/10412/Med/30/82/08
3 years
(2008-2011)
02 Role of LOX and Homocysteine in the aqueous humor and the plasma of patients with PXE syndrome
(PI: Dr. N. Angayarkanni)
ICMR
52/18/2002-BMS
2 years
(2009-2011)
03 Experimental study on the potential antiglycating effects of a novel mixture of amino acids on hyperglycemia induced retinal changes.(PI: Dr. N. Angayarkanni) CSIR
27(0215)/09/EMR II
2 years
(2009-2011)
04 Identifying compounds which potently inhibit MMP 2, 9: therapeutic applications for retinal diseases.
(PI: Dr. N. Angayarkanni)
CSIR
27(0219)/09/EMR II
2 years
(2009-2011)
05 Effects of the pesticide chloryrifos on the proteome of human retinal pigment epithelial cell line (ARPE-19). (PI: Dr. N. Angayarkanni) ICMR
5/8/4-18(Env)/08-NCD-I
2 years
(2010-2012)
06 Studies on thiolation and homocysteinylation of serum proteins in the two retinal diseases – ARMD and ED. (PI: Dr. S. Ramakrishnan) ICMR
52/16/2007-BMS
2 years
(2009-2011)