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Department of Biochemistry and Cell Biology

Projects
On Going Projects
 
Sl.No Title of the projects & PI Funding Agency & No. Duration

1

Tear Proteomics profile in Rheumatoid arthritis patients associated with and without Dry eye syndrome
(PI: Dr. N. Angayarkanni)


DBT
PR/10412/Med/30/82/08
3 years
(2008-2011)

2

Role of LOX and Homocysteine in the aqueous humor and the plasma of patients with PXE syndrome
(PI: Dr. N. Angayarkanni)


ICMR
52/18/2002-BMS

2 years
(2009-2011)

3.

Investigation Into The role of lipids, BDNF and VEGF in Diabetic Retinopathy. (PI: Dr. N. Angayarkanni)


DBT
PR11627/MED/30/157/08
3 years
(2009-2012)

4.

Experimental study on the potential antiglycating effects of a novel mixture of amino acids on hyperglycemia induced retinal changes. (PI: Dr. N. Angayarkanni)

CSIR
27(0215)/09/EMR II
2 years
(2009-2011)

5.

Identifying compounds which potently inhibit MMP 2, 9: therapeutic applications for retinal diseases.
(Co-PI: Dr. N. Angayarkanni)


CSIR
27(0219)/09/EMR II
2 years
(2009-2011)

6.


Effects of the pesticide chloryrifos on the proteome of human retinal pigment epithelial cell line (ARPE-19). (Co-PI: Dr. N. Angayarkanni)



ICMR
5/8/4-18(Env)/08-NCD-I
2 years
(2010-2012)

7.

Role of adiponectin on the integrity of Blood retinal
barrier during diabetic retinopathy using an in vitro 3D
cell culture model. (PI: Dr. J. Subbulakshmi)


DBT (RGYI)
PR15023/GBD/27/282/10
3 years
(2011-2014)

8.

Characterization of a novel 88 kDa protein found in patients
with Eales’ disease, Uveitis, tuberculosis, leprosy and
rheumatoid arthritis (PI: Dr. K.N. Sulochana)


ICMR
53/9/2001
2 years
2011-13

9.

Adiponectin as a “therapeutic target” for ocular angiogenesis (PI: Dr. K.N. Sulochana)

ICMR
5/4/6/6/09-NCD II
2 years
(2010-2012)

10.

Development of siRNA by targeting copper regulators to control
angiogenesis (PI: Dr. K.N. Sulochana)

DBT
PR/2885/AGR/36/620/09
3 yrs
(2010-2013)

11.

Development of a simple fluorescent assay for serum LOX
activity (PI: Dr. K.N. Sulochana)

ICMR
52/6/2009-BMS
2 yrs
(2010-2012)

12.

Design and development of small therapeutic peptide to target
Angiogenesis by regulating LOX (PI: Dr. K.N. Sulochana)

CSIR
27(0241)/10/EMR II
3 years
2011-14

13.

Studies on thiolation and homocysteinylation of serum proteins in the two retinal diseases – ARMD and ED.
(Co-PI: Dr. K.N. Sulochana)

ICMR
52/16/2007-BMS
2 years
(2009-2011)

14.

Development of therapeutic peptides from small proteoglycan LRR family for the inhibition of tumor angiogenesis.
(PI: Dr. K.N. Sulochana)

DBT
PR13198/Med/30/245/09
2 yrs
(2011-2013)

15.

Investigating the therapeutic potential of LOX propeptide in angiogenesis and tumorogenesis (PI: Dr. K Coral)

DST FAST TRACK
No. 0071/2010
2 yrs
(2010-2013)

16.

Identification of interacting partners for PEDF in causing anti-angiogenesis ((PI:Dr.K.N. Sulochana)

DST
SR/SO/JS/0099/2010
3 yrs
3 yrs

17.

Screening of the AMD patients for PON polymorphism and its functional correlation at the level of the PON activity, OxLDL and Homocysteine in the blood (DR. N. Angayarkanni)

DBT 3 yrs
 
Completed Projects (2007-09)
PI: Dr. N. Angayarkanni
 
Sl. No Title of Project & Funding Agencies No. Amount Period & Year

1.

Activities of LOX and MMP in Cultured Bovine Retinal Pigment Epithelial Cells-Role of Retinoids in their Regulation.

(DBT: PR4853/BRB/10/358/2004)

Rs. 21.83 lakhs
2005 -08
3 years

2.

Effect of free amino acids on the insulin mediated signal transduction pathway in cultured CHO cells

(DST : BT/PR 10412/MED/30/82/2008)

Rs.16.5 lakhs 2005-08
3 years

3.

Study on the molecular mechanisms of amino acids at the level of signal transduction in retinal pigment epithelial cells, retinal capillary endothelial cells and Pericytes.

( ICMR: 52/18/2002-BMS)

Rs. 19 lakhs
2006-09
3 years

   
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